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Buffer filtration

Buffer solutions are required for such purification steps as chromatography, ultrafiltration, bottling, in the manufacture of pharmaceutical and biotechnological drugs. Typical buffers include sodium acetate, sodium phosphate. Typically, buffer solutions are filtered using membrane filters. Prefilters are used to extend the life of the final filters.

 

 

Process Requirements

 

Typical buffers with a low salt content usually do not require prefiltration.

 

For buffers with a high concentration of salts or in the presence of low-quality raw materials it is recommended to use a prefilter. The coordinated combination of the prefilter and the final filter provides a high flow rate and stability of the working resource.

 

Purposes of filtration

 

Finishing filtration

 

remove bacteria and particles.

 

Recommendations for filters Technofilter for the preparation of buffers

 

For the final sterilizing filtration, we recommend a HYPERLINK membrane filter  EPM-PS-045/020 based on a high-performance asymmetric polyethersulfone membrane.

 

For high-quality prefiltration of buffers with high salt concentration, we recommend deep prefilters  EPVSc or EPVS with a rating of 0.5-0.8 μm. The filter elements of these series are capable of providing high flow rates, excellent mechanical and thermal resistance, low resistance, high efficiency of microparticle retention, do not emit fibers into the filtrate, manufactured according to ISO 9001: 2000.

 

For sterilizing air filtration ("breathing" filters) we recommend membrane filter elements from polytetrafluoroethylene brand EPM.F4 or hydrophobic fluoroplastic F42 brand EPMF with 0.2 μm pore size.

 

 

For the organization of the filtration process, we offer enclosure equipment - medical  filter holders of the DS series from high-quality stainless steel AISI 316L or AISI 304 for different number and height of filter elements and filtration units on their basis.

 

 

 

For the final choice of the scheme for the process of filtering the buffers, please contact the specialists of  Technofilter LLC.


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